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Frequently Asked Questions

Institute for Precision Cardiovascular Medicine Frequently Asked Questions

The number of Pathway Grants to be awarded by calendar period is as follows:
2014-2015:  8
2015-2016: 6
2016-2017: 8
2017-2018: 6 
2018-2019: 6

One Challenge Grant will be awarded between July 1st and June 30th for each of the following years:  2014-2015, 2016-2017, and 2018-2019.

Yes, an individual can apply for both types of awards, however there can be no scientific overlap between the different award submissions.

Yes, multiple principal investigators are permissible per award.  

Yes, new data from new clinical/population samples exclusive or inclusive of FHS/JHS datasets or new enhanced data from other established cohorts may be used. 

Yes, both metabolomics and proteomic studies are within the scope of CVGPS grant mechanisms.

The integration of data sets from various sources may be particularly useful in the study of gene/phenotype and environment interactions or in enhancing risk factor prediction. For example, one might conduct a comparison of data on outcomes (and related gene/phenotype interactions) using data from the Centers for Medicare and Medicaid Services (CMS) in efforts to enhance characterizations of hospitalizations for selected outcomes of interest and characterizations of potential exposures to prescription medications not ascertained by the parent studies.

In all instances where external data will be used, investigators will still be required to adhere to the practices established by the parent studies of those databases to protect the quality and confidentiality of the data and samples.  

The addition of data and/or resources from new cohorts will be evaluated on a case-by-case basis by the CVGPS Scientific Oversight Committee and adhering to the data sharing policies and procedures of the new cohort studies.

Questions or comments should be directed to the American Heart Association via email to  You will receive an acknowledgement response typically within 72 hours.  Final answers to some inquiries may be more complex and require longer timeframes to determine, but in all instances you will be advised of the timeframe by an AHA staff member.

Yes. While no minimum percent effort is specified, the percentage effort of the PI will be part of the application and must demonstrate that adequate time will be devoted to ensure successful completion of the proposed project. 

Yes. (See question above). If the co-investigator has adequate time to devote to ensure successful completion of the proposed project, an intramural NHLBI investigator could be named as a co-investigator.

The award agreement will be made available to the recipient and their institution after notification of receipt of award.  The awardee will be expect to follow the regulations and policies of the grant programs of the AHA.

One institution will be named in the award agreement and distribution of funds is the responsibility of that institution. The expected funding distribution to collaborative institutions will be part of the application.  Deviation from that funding distribution will require an exception from the AHA.

Only one application may be submitted per investigator for each grant mechanism.   Multiple applications may be submitted from one institution.  Yes, an investigator could be the PI on one LOA and a co-investigator on another. 

Yes.  It is acceptable for a US Institution based Contact PI to have a financial relationship with a PI in a foreign country.  The AHA pays an award eligible US Institution and it is up to the Contact PI and the US Institution to distribute the dollars to the foreign institution and PI.

Currently direct funding of foreign institutions would be prohibited: Awards for research to be performed outside the United States are limited to Principal Investigators who are United States citizens. Awardees, who are US citizens, may request AHA approval to temporarily conduct work in foreign countries (e.g., outside US, Canada and Mexico) with AHA Award funds to be administered through a US institution. 

A training plan is required for all Pathway and Grand Challenge applications.  An Individual Development Plan (IDP) for the early career investigator is required with submission if the individual is identified at the time of application.

Discovery Grants do not require a training component. 

The requirement for fellows to devote 75% effort to research training refers to all research training as we do want a fellow associated with the project to be an individual who devotes essentially full time to research and training.  However, they are not required to devote 75% effort exclusively to the CVGPS project.

Also, the requirement that a fellow not hold another fellowship award was adapted from the AHA fellowship program.  In the case of the CVGPS program, AHA funding via this program might supplement other funding available to the fellow.  Consistent with our standards for other AHA awards, AHA will require that the stipend charged to the award for the fellow be commensurate with the percent effort devoted to this project.

No.  CVGPS grant mechanisms have a procedure in place that provides for initial scientific review by AHA prior to initiating the review processes at either JHS or FHS. By restricting submissions of AHA ancillary study requests to this process, we can avoid possible redundancy and confusion and thereby streamline the AHA/JHS/FHS review procedure.